University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

362

Pages:

3
Author:

Amal J.

Peroxisonal TargetingNH3+IPTS1( peroxitomal Targeling Sequence)coo[@c]SKLPex55Pex 5xeceptorADP+PiATPPexienergy forPex 6Pesc 5 toformation of multimericgo back to cytoso.complex with #PextH PescllyaddubiquitintagPex10erelease ofPex 5back tocytorolPex2 Pex12releaseby obiquitisationfor degradation. Polyuhiquitindeath tagmono ubiquitinmutation in peroxismal proteinsZellwiger SyndioneCrano facial abnormalities Lipase as ando (beliabwall (especially muscle capillary)remove fallyacidschilomicion remnantsformedenter liver cell(containchiomicon remant receptor)liver produceVLDL + Apol .100, E,Ccirculation, lipasesIDL + Apo B 100, E [lackc]LDL + ApoB 100All celltypes (liver) PM containDL receptorengulfing by recept mediatedendocytonreceptor recycled back to PM+ApoB 100 & lipid degradeFAenergy + productions membrone synthesis.Steroid hormone bioryn thesis, vit D3 LDL receptor- lypet single pass proveLDL - ligondligend binding domain exoplasmic side (extracelular side)NPXYsorting signal exposed+AP2 +clathrin bindinvaginateClatfrin require dynamin to pinch of b vesiclefrommembroneexpose Rab&SNAREvesicle nowfuse with en dosomeIrontransportInon + Apotransfeuinferotronsfeuinall cellshoove ferotronsfeuin receptorligond bindsClathrinendosomeonly iron release (unlike LDL)transferin travelbackinside endosomefe3t metaloreducture enzymeFeatFe 2+