Prostaglandin Synthase in Cellular Signaling

University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

92

Pages:

2
Author:

Amal J.

Prostaglandin synthase (bijunctionalenzyme)PeroxidaseCycloxygenaseEnzymeCox1 - mucus recreation in stomach.AspirinCox 2 - synthesis of prostaglandinsaspirin inhibitboth Cox1 & COX2leads to stomach irritationsmodified medicine discovered Cox- 1Bspecifically inhibitCox2,Cause HeartAttackCox1BSubstrate Analogs.Eg: TPCK Tosyl L phenyl alanine Chloro Methyl keton- Sobstrate analogue of chymotrypsin enzyme substrate3 bromo acetol Phosphate- abalogue of DHAP, the substrate of triesephosphateisomerase.Suicide Inhibitors.Eg: :- Penicillin- - AntibioticPinotalum.-suicide inhibitor- kill bacteriaGram +ve bacteriaNAM NAGPeptidoglycans.crosslin ked with a tetrapeptide to NAM. These tetra peptides are cross linked with a pentaglycine chaincrosslinking in done by an enzymetranspeplidaseGGPenicillinTranspeptidanewall formationfor gram -veno tetrapeptidewill not occur, gramave +velinkage.bactelia wont survive.howithecomes a suicidal inhibitorPenicillinTranspeptidanePencilloylInhibit transpeptidaseEg2: DeprenylDopamine and scrotonin levels are to be maintained in thebrain.Dopamine level Parkinsons diseaseSerotonin level depressionDopamine & SerolonisMonoamine oxidase.DeprenylDeaminated ,inactivated (reducedParkinson's disease / d epression