Vesicle Types in Intracellular Transport

University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

245

Pages:

3
Author:

Amal J.

veside typesEICop.II (coated vesicle pro tein - Cop)2Cop I3Clathrin coated vesicleendosome primature210/eredcoat1byerSec12,23,24.form oflysosome, not2layerSec13,31.acidic as lysomes\Cop IIER to cisgolgiendocyfosisvesicles - -endosonelSas (STTP associated GPeotein]carredproteingolgi pinches orderJose withlyscoone2Cop ICis golgi to ERSec12 GEF of Sar1ARF(KDELcontainingfor610(Gprotein)protein)D OTTPexposedLater to earlieshydrophilitermGolgiciternae cisternalmateration , enzyme retrival]3Clathris coatedtrons golge toendosome(proteinwithmannose -6P)(ARF)(AP1 / GGA complex)DynaminGTPPM to endosome (receptor mediatedhelps in(AP2 complex)endocytois)pinch off ofClalimin coatedGolgi to cysosome,vesiclemelanosoma/plateletevericPtype Ht ATPase(AP3 complex)Coatproteincurvaturemake lysonneacidicof membranemembronecargoexpose acytoplasmiccoatcurvaturesignalsortingproteinsofmembroneready tobetocytoolsignal (CSS)bindtransporteddonal mentra(CSS) of membrone caugogancoatprotein vsnale on donal membrone:soluble molein (caugobindsto TsparesDentagetmassoluble caugo receptor exposesSQahrondtn entable cauge once vesicle pinches offscot proteindisaasableby GrphydeolysisVsnare exposedTshare binding with vspareinteraction b/w T& Vsnale in very high so that they canovercome the repolsion and bindand juseSNARE - SolubletsnacevsnarN-elhylmaleinick AdaptorProtein Receptor.glodicExopinlommTargetmenbrasePMofcellV. - spasesT-sparesSynaplobrevis, VAMP,Systazin SNA P25Rab -GTP - -present in all vesicles}fosionRabeffector on target mentroneDisassembly of v- TsnalesNSF& d -SNAPuses ATPhydrolyxis.NSFvesicledockingsyntascin-2-SNA-VAMPRABGTPandSWARSRABthis23Targetmembrone effectorAndicaldisassamblycoilsofSNARE inbland cells take up this00one compartment to anotherlystroneCylosolk ERZGdgl Endosom2 cysosomeGolgeEKdecreasing order of pH ofcyloroldifferent compartments.lominal sorting signal- - exposed inlomen - Soluble proteins(1) KDEL Mannore 6 Pretreivalsignal.Peoloinswhichfunctions inside ER lumeshas this signal (ER resident solobleprotein)Recognised by KDELreceptor in cis-golgihelpsincoming back of proteins to ER lomen.if they are mis sorted to GolgrD(2) Mannone 6. -Psolubte cysoromal enzymes. after processingin cis golgiCytoplasmic Sorting Signal - Membrone Proteins(1) KKX XER resident membrone proteinorginine "(2) X RRXCopI(diacidic sorting signal)- -(3) Asp-> Ginwtamate.Caugo membrane proteins in E.R. (diacidic sortigCopll(4)NPXYLDL receptor in PM.signal-Clathrin AP2lowdensity lipoproteins5)3 YXXOmemb proteins in tronsgolgibasic Cop.no nacidic