Bisubstrate Reaction in Enzyme Catalysis | Swansea University - Edubirdie

University:
Swansea University
Course:
PM-133 | Evolutionary and Molecular Genetics
Academic year:

2023
Views:

322

Pages:

2
Author:

Amal J.

Bisubstrate Reactions Two Types of Bisubstrate Reactions: Single Displacement Reaction (SDR) Once all substrates are bound, the products will be released. Types: Ordered SDR: The order of substrate binding is specific. Example: Lactate Dehydrogenase (LDH) Pyruvate binds first, followed by NADH. Lactate and NAD+ are released. Random SDR: The order of substrate binding is random. Example: Creatine Phosphate Kinase (CPK) Creatine phosphate (CP) serves as an energy reserve in muscles, next to ATP. ATP can bind either first or second, and products are released randomly. Double Displacement Reaction (DDR) Involves transamination between an amino acid and a keto acid. Example: Aspartate and α-Ketoglutarate (αKG) Aspartate + αKG ⇌ Oxaloacetate (OAA) + Glutamate. Mechanism of DDR: Step 1: Aspartate binds to the active site of transaminase (with a keto group). Step 2: α-Ketoglutarate (αKG) interacts with the amino group at the active site, forming glutamate.

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