Scientists are constantly striving to make what was once thought of as impossible, possible. But, often in this race to break barriers, what holds back the scientific community is the ethical implications of their actions. With new gene-editing technology, such as CRISPR-Cas9 and TALENs, becoming well-known and easily accessible, genetic alterations are no longer an impossibility. The introduction of these...
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Recently, a scientist in China named He Jiankui, posted his results of gene-edited twins using CRISPR to prevent the embryos from contacting HIV, whose father was a HIV-positive. This incident raised heated and controversial debate about the premature gene-editing technology and whether its use is ethical on humans. Some support it, while most are concerned about the potentially harmful effects....
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Imagine being told that you have an incurable genetic disease and you will slowly die. There is no treatment to save your life, all you can pray for is a little bit of hope. Gene therapy is that hope that chance you may now have at surviving or living longer. Hi, my name is Grace and today I will be...
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Gene editing sometimes known as genome editing is a scientific process of deliberately altering slightly changed to the DNA of a cell or an organism. It uses advanced technological tools such as CRISPR/Cas9 which is said to make people’s lives better but not entirely ensuring a better future for the next generations yet to come. Germline genome editing which is...
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Gene Therapy Imagine if people living with life threatening diseases had the chance to have a second chance at life, with gene therapy that could be possible. Gene therapy is an experimental form of treatment that works by replacing a disease causing gene with a new working gene, or by introducing a new gene to cure a condition or make...
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Over the years genetic disorders and gene-related illness have been responsible for high mortality rates and reduced quality of life. Genetic disorders can be due to misalignment, missing genes or excess of a gene. Genetic therapy works to replace the defective genes with new ones. Gene therapy is the insertion of genes into an individual's cells and tissues to treat...
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A genetic disorder is a disease caused by a mutation or change in an individual’s DNA. Sometimes a whole or part of a gene is defective or missing from birth or can mutate later in life, which can disrupt how proteins are made. This affects the body’s systems and causes health problems and diseases, such as sickle cell, SCID, and...
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Gene therapy is an experimental method for correcting faulty genes that cause disease to develop. Gene therapy attempts to treat illness by altering a person's gene expression, with the ultimate goal of curing or preventing genetic diseases. Gene therapy aims to solve the problem at its source by inserting the right gene or repairing an existing one. Genes are the...
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Written in 1976 by Richard Dawkins, ‘The Selfish Gene’ discusses key concerns related to evolutionary processes. Initially, Dawkins, introduces the reader to the most prevalent theories at the time, notably the group centered theory of evolution proposed by various academics. The book proposes the alternative theory of a ‘gene centered’ view of evolution as opposed to the former theory. Lastly...
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Gene editing, a group of technologies that give scientists the ability to change an organism's DNA, is of vital importance in cell and gene therapy. CRISPR is a revolutionary gene editing technology which has become the hottest research tool in the field of biological sciences in just a few years since its introduction in 2012. However, people may still wonder...
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Abstract CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and CRISPR associated protein Cas9 has revolutionized gene and genome editing. This system was discovered in prokaryotes as a defence mechanism to protect themselves from viral predators via three basic steps of spacer-acquisition, Crispr RNA (crRNA) processing and interference. CRISPR-Cas display a prokaryotic adaptive immune system that memorize previous infection by integrating...
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Gene cloning is a biotechnology in which a section of DNA is isolated and extracted before being cloned using bacterial plasmids. To execute this process, a restriction enzyme isolates a specific gene from a strand of DNA and the plasmid, and then cuts the gene creating complementary sticky or blunt ends. These are joined to form recombinant DNA, which is...
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Abstract Amylase is an enzyme produced by the salivary glands and pancreas of Homo Sapiens to hydrolyse polysaccharides such as starch and glycogen (Tracey 2019). Variation in the number of AMY1A gene copies is thought to be a result of ancestral heritage and levels of consumed starch (Tracey 2019). Results from a previous study conclude there to be a positive...
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Abstract The following paper is about genetic disorders, the one in which has been discussed in great detail being hemophilia, the gene therapies for such genetic diseases and the advancement that have been made in this particular field of study. As you read you find the definition of gene therapy and what it involves as well as how genetic diseases...
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Gene therapy can pose great risks such as short-lasting effects, generational effects, and worst case; deaths. Since there are great risks to each case there are many ethical questions in line with the use of gene therapy. It can be hard to weigh the pros and cons, when it comes to such sensitive topics. For example, as demonstrated in the...
Gene
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Gene therapy is the process through which healthy genetic code is included in cells to replace abnormal genes or create a desirable protein. Researchers explore various gene therapy strategies to resolve problems such as mutated gene replacement with a healthy gene code. This deactivates any mutated genes and adds a healthy gene into the body to help tackle a genetic...
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Gene therapy is a technique that uses genes to treat or prevent disease. Gene therapy replaces a mutated gene that causes disease with a healthy copy of the gene. Introducing a new gene into the body helps fight a disease (U.S department of health and human services (2019)-gene therapy. Retrieved from ghr.nlm.nih.gov). Gene therapy uses viruses to deliver DNA in...
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Due to the negative effects of antibiotics on environment and the resistance of bacteria’s to them a variety of useful feed supplements, including probiotics, prebiotics and synbiotics having beneficial effects to the host was commercially produced. Recently the segment of food industry and aquaculture researchers has encouraged the development of dietary supplements with prebiotic properties, looking for the health promotion,...
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The idea of tinkering with the genes becoming a part of future generations has always existed as a muse in science fiction. Now, we have the technology and choice to change the course that thousands of years of biological evolution have taken us on. And it comes in the form of a pair of molecular scissors called ‘CRISPR’. With this...
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Introduction Gene therapy typically involves the insertion of a functioning gene into cells to correct a cellular dysfunction or to provide a new cellular function. For example, diseases such as cystic fibrosis, combined immune deficiency syndromes, muscular dystrophy, hemophilia, and many cancers result from the presence of defective genes [1]. Gene therapy is basically to correct defective genes responsible for...
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Gene editing and enhancing, which allows for a particular area in the genome to end up being targeted and changed by deleting, substituting or adding nucleotides, is currently the subject matter of very much academics, policy, and industry discussions. While not really fresh per se, gene editing has become a particularly salient topic mainly due to a relatively novel tool...
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What is gene cloning and how does it work? DNA cloning is the process of creating multiple identical copies of a piece of DNA extracted from an organism. The very first step of making insulin is the synthetic creation of this human insulin gene. The human insulin gene is at the top of chromosome 11 in humans. Firstly there is...
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Throughout the world there are many dangers to the health of humans—war, climate change, and resource scarcity are just a few. However, one of the largest threats to the well-being of the human species is disease. Specifically, genetical diseases such as those that infants are born with. With these diseases come scientific endeavors to try and remedy the illnesses. One...
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Cracking our codes becomes reality step by step. First the Watson-Crick DNA structure, then the whole genome project, and now CRISP-R gene editing lights the way of the human code cracking. I think the gene editing on embryos should be legalized. There were many new treatments in the medication history and at the beginning they were all controversial issues. Since...
Gene
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During the past few years, there has been a demand for fish and marine products, and this demand has led to a rapid growth of the aquaculture industry (Myhr et al. 543-544). The development of genetic engineering technologies offers the opportunity to increase marine crop diversity, add traits to meet consumer preferences and overall increase productivity (Shukla-Jones et al. 11-13)....
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Abstract Haemoglobin is a protein found in the red blood cell (RBC), which consists of 4 protein components in which 2 of the components are called alpha-globin and the other 2 are called beta-globin. This protein helps to carry oxygen around the body’s tissues and organs. This investigation focuses on beta-globin. The purpose of this investigation is to find out...
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Abstract Gene therapy has gained large interest in the scientific field for potential therapeutic applications since the development of CRISPR/Cas9 genome editing techniques. The effectiveness of CRISPR/Cas9 to treat disease has been demonstrated in studies regarding HIV, liver disease, and triple negative breast cancer, but little is known about its ability to treat oculocutaneous (OCA1) albinism. OCA1 albinism is associated...
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Gene mutation is defined as a permanent alternation in the DNA sequence which makes up a gene that makes the DNA sequence differs from that of most people. Gene mutation could be further divided into two types which are hereditary mutations and acquired mutations. The difference between hereditary mutations and acquired mutations is that hereditary mutations are inherited from a...
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As Valle (n.d) pointed out “In editing the human genome, scientists must worry about unintended consequences, changes to other parts of the genome that are called off-target effect. Fix one thing, we have broken something else. (as cited in Hopkins, 2017)”. In other words, by developing technologies, scientists have tried out all possible ways of modifying the genes of animals,...
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Introduction The Human Genome Project was the start of an era of exploration into what makes people tick. The Project helped to identify and map all of the genes of the human genome from both a physical and a functional standpoint. The fulfillment of the Human Genome Project allowed researchers to pinpoint what genes were mutated and liable for certain...
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