Rationale Gregory in the Daily Mirror claimed that ‘All inherited diseases could be cured within 20 years thanks to gene editing breakthrough’ (Gregory, 2017). After initial research, a draft question ‘Can Hemophilia A (HA) be cured with Gene Therapy?’ is posed. “Gene editing” biotechnology is...
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The clinical symptomatology of Alzheimer’s disease (AD) is considered to be the result of an extensive destruction or disorganization of the cerebral cortex, as the patient’s cognitive functions become impaired. Late onset Alzheimer’s disease affects 5-10% of people over the age of 65 years old...
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Gene editing in agriculture Gene editing involves making distinct changes in the DNA sequence of a plant/animal cell creating a desired genetic make-up. Gene editing is a powerful tool for genome editing which requires high specificity and uses enzymes known as nucleases which cut the...
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Abstract DNA cloning and expression vectors are the modern-day mainstays for molecular biology studies. In Spite Of advances in synthetic biology and modern techniques, researchers around the world still uses the standard way of DNA cloning, using plasmids and reporter proteins for selecting possible recombinant...
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In Australia Gene editing technology is fast on the rise and has large potential for change in the future and therefore must be legislated and monitored with great care for the benefit of Australia and its inhabitants. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) allows...
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The cloning process is taking cells from an individual and replicating genes or DNA. In the process of cloning the gene is entered in the plasmid, which is a piece of the DNA (Overview: DNA cloning, 2019). There are four steps into the cloning process...
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There are several physiological changes that occur during normal pregnancy, hypercoaggulabilty state is one of them in which some coagulation factors increased in blood in harmony with decreased blood level of others. These changes are needed for normal fetal growth and development with complete return...
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ABSTRACT Inter specific hybridization was made between susceptible greengram variety CO 5 and wild Vigna sp. Crossed seeds were raised in field condition for testing the MYMV incidence. F1 showed dominant resistance reaction against MYMV disease incidence. The field growing F2 populations of C0 5...
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Gene Therapy consists of modifying the genes within somatic cells to treat or prevent a disease. The reason this is possible is because genes contain our DNA, which is what decides a huge part of a person and what they look like. When a gene...
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A gene is a nucleotide sequence which dictates the synthesis of a particular RNA or protein molecule. Their control over the produced proteins govern both phenotypical and genetic traits, including susceptibility to diseases like Cystic Fibrosis. Driving gene expression is Central Dogma, a two-step process...
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Germline gene therapy has developed a wide spread of opinions into the regards of its ethics with many very relevant positive and negative opinions being expressed amongst the breakthroughs occurring within its progress. There are lots of varying factors contributing towards these ethics which both...
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First recognized in 1926, ataxia-telangiectasia, otherwise referred to as AT, is an extremely rare and ineluctably progressive disease which slowly denigrates the nervous system. Ataxia–telangiectasia is an autosomal recessive, caused by mutations in the ataxia–telangiectasia mutated gene (ATM), which is best described as a serine/threonine...
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Life is a DNA driven programme and death results from its technical failure. Protein and DNA were evolved naturally from the gas present in the environment of the primitive world. It was the effect of high voltage thunderbolts and asteroid hits on the surface of...
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Abstract In today’s society, there are numerous children that are born with a childhood disease that is life-threatening. Many children do not live past the age of five with some of these debilitating diseases. As a result, researchers are tackling the crisis by editing the...
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Abstract Horizontal gene transfer (HGT) has a great role as a driving force in the evolution of prokaryotes and eukaryotes and has occupied a major role in evolutionary thinking. Many studies have shown how prokaryotic evolution has been manipulated by HGT such as the spread...
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Diseases come in various types and subtypes and they all possess diverse underlying mechanisms. A common factor in all of them is the influence of the genetic background that is unique to every individual. The presence of susceptibility genes and modifier genes in our genome...
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ABSTRACT To take complete advantage of the large and rapidly increasing body of sequence information, advanced technologies are very much required. Among the most powerful tools for genomics are high-density arrays of oligonucleotides or cDNAs. Exploration of the genome using DNA microarray should narrow the...
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INTRODUCTION Motor neuron diseases (MNDs) are a group of neurodegenerative diseases with progressive degeneration of motor neurons (MNs) that lead to muscle weaknesses, loss of ambulation, and chronic disability, ultimately causing premature death in patients (Cappella et al., 2019). Two representative examples are spinal muscular...
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Long before gene-editing technology became available, public debate over the ethics of using the technology to treat humans had been raged. Immense promises and worst fears associated with modern biomedicine reasoned the intense ethical interest in the technology. All believed that there was something exceptional,...
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CRISPR (clustered regularly interspaced short palindromic repeats), which is a technology allowing scientists to edit genes in living cells, has ignited a revolution. Even though it is a relatively recent discovery in the history of biomedicine, CRISPR has entered mainstream use in research swiftly. In...
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There are many different types of viral vectors that are used to deliver a corrected CFTR gene. The Adenoviral vector was one of the first vectors to be tested to see if it couls successfully deliver the corrected gene. Ad vectors don’t become a part...
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The field of genetic engineering and specifically gene editing has grown significantly in the last decade with the creation of Clustered Regularly Interspaced Short Palindromic Repeats – Cas9, or CRISPR, and the emergence of gene manipulation. This technology can be very risky or valuable based...
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The Foundation of CRISPR Clustered regularly interspaced short palindromic repeats or CRISPR as it is more commonly known would not be possible without the many scientific discoveries that enabled scientists to understand DNA. Many discoveries enabled this, such as Watson and Crick and Rosalind Franklin,...
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Imagine a future in which parents can give their unborn child the best genetic traits possible, grooming them for genetic perfection. Through genetic testing and gene therapy, modifying and enhancing genetic attributes is becoming a reality. These industries are growing rapidly, with 1,000 genetic tests...
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A Congenital Diaphragmatic Hernia is a birth defect that causes a tear in the diaphragm that pushes abdominal organs into the chest cavity, therefore, preventing proper lung development. CDH occurs in one out of 3,000 live births, and has a high mortality and morbidity rate...
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CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats (Broad Institute, 2019) is a relatively new discovery in genetic sciences with many useful applications across many fields. CRISPR is extracted from a bacterium and was initially thought of to be a part of bacterial immune system....
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Introduction Gene editing focuses on inserting DNA, deleting it or modifying it, or in some cases even replacing it in the genome of the chosen organism (Richter, 2016). Clustered regular interspaced short palindromic repeats (CRISPR) is seen as an innovating piece of technology and a...
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INTRODUCTION The TNXB gene is cytogenically located at the histocompatibility complex III on chromosome 6 in the human genome (6p21.33- p21.32). The gene has a unique structure as it overlaps with other genes by embedding its 5’ and 3’ end in CREBL1 and CYP21 genes...
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Up until recent years, illnesses such as cystic fibrosis, Alzheimer’s, leukemia, and many more diseases have been classified as incurable. These lifelong ailments have brought despair and hopelessness onto the lives of many people. However, with the recent break in scientific technology and the gene...
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Gene tampering can lead to unforeseen issues when altering the expression and the existence of gene patterns. The suppression or replacement of gene’s patterns can lead to things such as an extinction of cultures, races, and subjective undesirable traits. The tampering with Genes has been...
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