Pancreatic Cancer essays
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Introduction Pancreatic cancer (PC) is highly lethal malignancy and consider the fourth most common cause of cancer-related deaths worldwide. The majority of patients, approximately 80%, are diagnosed at an advanced and incurable stage, advanced local (III) or metastatic (IV), of disease, and only around 20% of cancers are suitable for surgical resection. The prognosis for PC is extremely poor, with only 7% five-year survival rate. Few chemotherapy treatments have been shown to slightly improve survival for advanced pancreatic cancer patients,...
4 Pages
1737 Words
Abstract: Epigallocatechin-3-gallate (EGCG) is a polyphenol from green tea extract is known to suppress the human pancreatic cancer in-vitro. Its anti-proliferative action mediated by caspase-3-activation, nuclear condensation and poly-ADP ribose polymerase cleavage. Pancreatic cancer cell death by EGCG is mediated by arresting growth at an initial stage of cell cycle. EGCG involves depolarisation mitochondrial membrane to allow cytochrome-c release into cytosal. EGCG increased the production of intracellular release oxygen species (ROS), along with C-Jun-N-terminal kinase activation in pancreatic carcinoma cells....
2 Pages
838 Words
‘Cancer’ - a word so small yet so destructive. In fact, in 2017, in the UK alone there was an astonishing 4 million cases and 9.56 million deaths worldwide. An inevitable disease that just continues to increase in size. As the philosopher Desiderius Erasmus once said, ‘prevention is better than cure’ - this is most certainly the case with cancer. Cancer survival rates are the highest they have ever been. A way to improve survival rates even further is for...
3 Pages
1258 Words
Pancreatic Cancer Pancreatic cancer is a silent killer and “is the fourth leading cause of death in the United States” (Reynolds and Folloder, 2014, p. 356). “Pancreatic cancer will often develop without clear early signs or symptoms, and the eventual manifestations will depend on the tumor location within the gland” (Reynolds and Folloder, 2014, p. 357). Pancreatic cancer is of significant concern for nursing because the signs and symptoms are very broad and can overlap with other disease processes. Pancreaticoduodenectomy...
5 Pages
2473 Words
Abstract Introduction Predicting the clinical outcome in pancreatic cancer is often challenging due to the lack of reliable and cost-effective prognostic parameters. Red Cell Distribution Width (RDW), an index of the variability in the size of the circulating RBCs has been reported to have prognostic significance in some malignancies. However, there is a scarcity of literature supporting its relevance in pancreatic cancer. Objective To study the association between RDW and tumour stage in patients with pancreatic cancer attending a tertiary...
5 Pages
2339 Words
Introduction Cancer epidemiology Cancer biology Carcinogenesis Molecular basis of cancer Cancer metastasis Pancreatic cancer Epidemiology In the current age of the cancer research, pancreatic ductal adenocarcinoma (PDA) is one of the most hostile and deadly cancer worldwide (Zhuo-Xin Cheng et al., 2011). Pancreatic cancer is a sixth leading cause of death due to cancer in Europe and in United States it is the sixth due to because of various reasons like poor diagnosis as well as prognosis, lack of screening...
5 Pages
2199 Words
