Abstract Introduction Predicting the clinical outcome in pancreatic cancer is often challenging due to the lack of reliable and cost-effective prognostic parameters. Red Cell Distribution Width (RDW), an index of the variability in the size of the circulating RBCs has been reported to have prognostic significance in some malignancies. However, there is a scarcity of literature supporting its relevance in pancreatic cancer. Objective To study the association between RDW and tumour stage in patients with pancreatic cancer attending a tertiary...
5 Pages
2394 Words
Abstract Pancreatic cancer (PC) is characterized by high mortality and poor prognosis, due to difficulties in early diagnosis and limited therapeutics. Although there is an intervention window before preneoplastic lesions advance to invasive PC, effective prognosis remains a hurdle using current biomarkers and imaging techniques. Biomarkers with significant prognostic efficacy and convenient analysis methods are urgently required. Hence, this study aimed to identify a potential biomarker for pancreatic cancer through an in-silico analysis of the Human Protein Atlas. Filtering yielded...
5 Pages
2440 Words
āCancerā – a word so small yet so destructive. In fact, in 2017, in the UK alone there was an astonishing 4 million cases and 9.56 million deaths worldwide. An inevitable disease that just continues to increase in size. As the philosopher Desiderius Erasmus once said, āprevention is better than cureā – this is most certainly the case with cancer. Cancer survival rates are the highest they have ever been. A way to improve survival rates even further is for...
3 Pages
1269 Words
Discussion Cancer is described as a disease that is characterized by excessive proliferation of cells and of their inability to die. Normally, cells can kill themselves in a balanced process known as āapoptosisā. It is becoming clear that too little cell suicide by apoptotic process can lead to a variety of cancers, including pancreatic cancer. Further investigation suggested that EGCG has Antiproliferative action on pancreatic cancer cells and this Antiproliferative action is mediated through Programmed cell death or apoptosis. Although...
6 Pages
2549 Words
Pancreatic Cancer Pancreatic cancer is a silent killer and āis the fourth leading cause of death in the United Statesā (Reynolds and Folloder, 2014, p. 356). āPancreatic cancer will often develop without clear early signs or symptoms, and the eventual manifestations will depend on the tumor location within the glandā (Reynolds and Folloder, 2014, p. 357). Pancreatic cancer is of significant concern for nursing because the signs and symptoms are very broad and can overlap with other disease processes. Pancreaticoduodenectomy...
5 Pages
2444 Words
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Introduction Cancer epidemiology Cancer biology Carcinogenesis Molecular basis of cancer Cancer metastasis Pancreatic cancer Epidemiology In the current age of the cancer research, pancreatic ductal adenocarcinoma (PDA) is one of the most hostile and deadly cancer worldwide (Zhuo-Xin Cheng et al., 2011). Pancreatic cancer is a sixth leading cause of death due to cancer in Europe and in United States it is the sixth due to because of various reasons like poor diagnosis as well as prognosis, lack of screening...
5 Pages
2237 Words
Introduction Pancreatic cancer (PC) is highly lethal malignancy and consider the fourth most common cause of cancer-related deaths worldwide. The majority of patients, approximately 80%, are diagnosed at an advanced and incurable stage, advanced local (III) or metastatic (IV), of disease, and only around 20% of cancers are suitable for surgical resection. The prognosis for PC is extremely poor, with only 7% five-year survival rate. Few chemotherapy treatments have been shown to slightly improve survival for advanced pancreatic cancer patients,...
4 Pages
1735 Words
Abstract: Epigallocatechin-3-gallate (EGCG) is a polyphenol from green tea extract is known to suppress the human pancreatic cancer in-vitro. Its anti-proliferative action mediated by caspase-3-activation, nuclear condensation and poly-ADP ribose polymerase cleavage. Pancreatic cancer cell death by EGCG is mediated by arresting growth at an initial stage of cell cycle. EGCG involves depolarisation mitochondrial membrane to allow cytochrome-c release into cytosal. EGCG increased the production of intracellular release oxygen species (ROS), along with C-Jun-N-terminal kinase activation in pancreatic carcinoma cells....
2 Pages
847 Words
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