How To Apply Nanotechnology To Control Pharmacoresistant Epilepsy

  • Words: 450
  • |
  • Page: 1
  • This essay sample was donated by a student to help the academic community. Papers provided by EduBirdie writers usually outdo students' samples.
Download PDF

The use of drug nanocarriers in pharmacoresistant epilepsy is potentially a very useful tool that can be applied to overcome the drug delivery problem. Developing this technology requires a multidisciplinary approach involving the collaborative work of nanotechnology and pharmacology specialists.

However, development of these models requires prolonged experimental periods and low (20 percent or less) percentage of pharmacoresistant subjects obtained (127). Repeated administration of 3-mercaptopropionic acid or pentylentetrazol (47, 128) is a short-term alternative for obtaining animals with overexpression of brain transporters. These procedures however do not induce spontaneous seizure.

Save your time!
We can take care of your essay
  • Proper editing and formatting
  • Free revision, title page, and bibliography
  • Flexible prices and money-back guarantee
Place Order

Other significant criteria to be considered in the production of nano-sized carriers for AEDs as therapeutic options for pharmacoresistant epilepsy include: 1) nanosystems must be engineered in such a way that AEDs can be masked and bypass the effects of multi-resistant proteins on the BBB that enable penetration into brain parenchyma 2) nanosystems must lead to successful prism.

Among the various types of nanosystems currently evaluated, MnPs have proven to be one of the best strategies for different biomedical uses, such as MRI contrast agents, cell therapy, tissue repair, hyperthermia ablation, drug delivery and carrier systems (140-142). MnPs offer special advantages such as their small size (< 100nm) in addition to their easy and economical synthesis process Suitable for cell membrane penetration (114, 143). Their biodegradability is performed by lysosomal rupture of the iron oxide core resulting in iron ions that are incorporated back into the hemoglobin pool (144) Given the magnetic characteristics of MnPs, intracerebral release from special devices may be controlled by magnetic fields (145) Some reports indicate that MnPs are highly biocompatible and do not induce toxic effects from their administration (146-148). MnPs may represent an excellent strategy for delivering AEDs into the brain parenchyma of patients with pharmacoresistant epilepsy according to this research. Indeed, a previous study indicates that 4 weeks of intraperitoneal administration of MnPs is not producing 'apparent' toxicity, Histopathological changes or adverse effects on the development and conduct of the body (149) However, it is necessary to note that MnPs in the biological environment are also reactive and can cause chemical interactions and toxicological effects (150, 151). On this issue, the MnPs are described as being able to Produce excessive reactive oxygen species, a situation which can result in oxidative stress (152, 153), neuronal damage, proinflammatory effects and BBB permeability modifications (154). Oxidative stress can cause cell death due to damage to the mitochondrial membrane or a malfunction of the electron chain (150, 155), Mutagenesis (156), activation of oncogenes such as Ras (157) or production of end-products detrimental to DNA (158) and subsequent cancer (159). Therefore it is important to determine whether adverse effects are produced after chronic administration of MnPs under different physiological conditions.

Make sure you submit a unique essay

Our writers will provide you with an essay sample written from scratch: any topic, any deadline, any instructions.

Cite this Page

How To Apply Nanotechnology To Control Pharmacoresistant Epilepsy. (2021, October 01). Edubirdie. Retrieved May 27, 2022, from https://edubirdie.com/examples/how-to-apply-nanotechnology-to-control-pharmacoresistant-epilepsy/
“How To Apply Nanotechnology To Control Pharmacoresistant Epilepsy.” Edubirdie, 01 Oct. 2021, edubirdie.com/examples/how-to-apply-nanotechnology-to-control-pharmacoresistant-epilepsy/
How To Apply Nanotechnology To Control Pharmacoresistant Epilepsy. [online]. Available at: <https://edubirdie.com/examples/how-to-apply-nanotechnology-to-control-pharmacoresistant-epilepsy/> [Accessed 27 May 2022].
How To Apply Nanotechnology To Control Pharmacoresistant Epilepsy [Internet]. Edubirdie. 2021 Oct 01 [cited 2022 May 27]. Available from: https://edubirdie.com/examples/how-to-apply-nanotechnology-to-control-pharmacoresistant-epilepsy/
copy
Join 100k satisfied students
  • Get original paper written according to your instructions
  • Save time for what matters most
hire writer

Fair Use Policy

EduBirdie considers academic integrity to be the essential part of the learning process and does not support any violation of the academic standards. Should you have any questions regarding our Fair Use Policy or become aware of any violations, please do not hesitate to contact us via support@edubirdie.com.

Check it out!